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Dr. Frankie's Blog Posts


The “N” in DIGIN: The Enteric Nervous System and the Conductor of Gut Health
When clinical interventions in the "G" (Microbiota) or "I" (Immunity) pillars fail to yield progress, the missing link is almost always the Enteric Nervous System (ENS) . Often described as the "second brain," the ENS contains more neurons than the spinal cord and manages the complex, rhythmic labor of digestion. This system is continuously modulated by the brain via the vagus nerve , a bidirectional communication highway where 80 to 90 percent of the information actually flo
Frankie Gan
Apr 164 min read


The "I" in DIGIN: Intestinal Permeability and the Gut's Gatekeeper Function
"Leaky gut" is one of those terms that provokes strong reactions. Some patients have been told it explains everything wrong with their health. Others have been assured it is not real at all. In clinical practice, intestinal permeability is a normal, tightly regulated physiological process. However, when regulation is lost, symptoms that once seemed unrelated may begin to appear. The gut lining is thin and precise by design The intestinal lining is only one cell thick. That t
Frankie Gan
Mar 134 min read


Why Small Intestinal Bacterial Overgrowth (SIBO) Keeps Coming Back—and How to Prevent It
“Doctor, I wake up feeling fine. But by late afternoon, my stomach looks and feels swollen no matter what I eat.”That line shows up in clinic more often than you’d think. Sometimes it comes with gas, sometimes cramping, and sometimes constipation for weeks followed by sudden loose stools—or a frustrating mix of both. Many people have already tried cutting gluten, dairy, or whole food groups. A few feel better briefly. Others are told their tests are normal and start wondering
Frankie Gan
Nov 25, 20254 min read


Interpreting Your Lab Panel the Integrative Way
Lab results are useful—but only when read in context. In a functional–integrative model, I’m reading for drivers (inflammation/oxidative stress, mitochondrial energy, immune tone, nutrient status, hormones, gut–brain imbalances) and pattern clusters that explain what you feel day to day. One driver can produce many pictures. Chronic, low-grade inflammation, for instance, may look like joint pain, skin flares, brain fog, insulin resistance, slower recovery, or sleep that nev
Frankie Gan
Oct 28, 20253 min read


Functional Medicine, Explained
If you’re health-conscious, dealing with nagging symptoms, or aiming to age well with steady energy and clear thinking, this page explains how I practice—and why it may feel different from a typical clinic visit. Why I practice this way (a personal note) Early in my clinical practice, I kept meeting people whose tests looked “normal,” yet they didn’t feel well . Conventional medicine is excellent for diagnosing and treating specific diseases. But it often lacks the whole-syst
Frankie Gan
Oct 16, 20253 min read
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